ForenSeq Universal Analysis Software (UAS) provides a next-generation sequencing (NGS) platform for analyzing and managing forensic genomic data, simplifying complex bioinformatics. Offering two applications, one for mitochondrial DNA (mtDNA) workflows and one for DNA Signature workflows, ForenSeq UAS rapidly generates FASTQ files, performs alignment, and calls variants from NGS data. Extensive testing backs highly reliable variant calls to deliver accurate results in a user-friendly package with zero per-seat licenses.